| Autor: |
Mosrin M; Department Chemie and Biochemie, Ludwig-Maximilians-Universität, München, Germany., Knochel P |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2008 Jun 19; Vol. 10 (12), pp. 2497-500. Date of Electronic Publication: 2008 May 29. |
| DOI: |
10.1021/ol800790g |
| Abstrakt: |
Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl.LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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