Endothelin B receptors on vascular smooth muscle cells of the human umbilical vein mediate vasoconstriction.
| Autor: | Mildenberger E; Department of Pediatrics, Charité, Berlin, Germany. eva.mildenberger@web.de, Biesel B, Siegel G, Versmold HT |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Fetal diagnosis and therapy [Fetal Diagn Ther] 2008; Vol. 24 (1), pp. 67-70. Date of Electronic Publication: 2008 May 27. |
| DOI: | 10.1159/000132410 |
| Abstrakt: | Objective: To test the hypothesis that smooth muscle cells of the human umbilical vein have vasoconstricting endothelin B (ETB) receptors. Methods: In strip preparations of human umbilical veins isometric tension after exposure to the selective ETB receptor agonist sarafotoxin S6c (S6c) was compared to the tension before S6c exposure (set as 100%). Results: In intact preparations S6c induced vasoconstriction only at the highest concentration applied (10(-8)M; 149.5 +/- 12.5 vs. 100%, p < 0.05). In contrast, in endothelium-denuded preparations S6c induced vasoconstriction already at the lowest S6c concentration investigated (10(-11)M; 111.7 +/- 4.3 vs. 100%, p < 0.05). Conclusions: The vasoconstricting effect of S6c in endothelium-denuded human umbilical vein preparations points to smooth muscle cell ETB receptor activation. (Copyright 2008 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|