| Autor: |
Lyng H; Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, NO-0310 Oslo, Norway. heidi.lyng@rr-research.no, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T |
| Jazyk: |
angličtina |
| Zdroj: |
Genome biology [Genome Biol] 2008; Vol. 9 (5), pp. R86. Date of Electronic Publication: 2008 May 23. |
| DOI: |
10.1186/gb-2008-9-5-r86 |
| Abstrakt: |
Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers from clinical array comparative genomic hybridization data. The tumor cell fraction is reliably estimated in the model. Data consistent with FISH results are achieved. We demonstrate significant improvements over existing methods for exploring gene dosages and intratumor copy number heterogeneity in cancers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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