| Autor: |
Kulabukhov VV; Department of Anesthesiology and Resuscitation, Purulent-Septic Surgery Clinic of National Medical Surgery Center N. Pirogov, Moscow, Russia. Vkulabukhov@gmail.com |
| Jazyk: |
angličtina |
| Zdroj: |
Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2008 Aug; Vol. 52 (7), pp. 1024-5. Date of Electronic Publication: 2008 May 20. |
| DOI: |
10.1111/j.1399-6576.2008.01677.x |
| Abstrakt: |
Methods for lipopolysaccharide (LPS) (endotoxin) reduction have been proposed as one way to improve the treatment of Gram-negative sepsis. Here we present a case with severe Gram-negative sepsis, treated with a novel device for LPS adsorption (Alteco LPS Adsorber, Alteco Medical AB, Lund, Sweden). After LPS adsorption, the level of LPS in the patient's bloodstream was almost eliminated: from 1.44 EU/ml before treatment to 0.03 EU/ml post treatment). The procalcitonin level and inflammatory cytokines were concurrently reduced. Also, an obvious improvement in the status of the patient's hemodynamics was seen. Forty-five days after treatment the patient is still alive. In conclusion, LPS adsorption may represent a significant improvement in the treatment of Gram-negative sepsis and further studies are planned. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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