Seroconvertion to hepatitis B vaccine after weight reduction in obese non-responder.

Autor: Dinelli MI; Department of Pediatrics, Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, SP, Brazil. beldin@terra.com.br, Moraes-Pinto MI
Jazyk: angličtina
Zdroj: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2008 Mar-Apr; Vol. 50 (2), pp. 129-30.
DOI: 10.1590/s0036-46652008000200013
Abstrakt: Decreased responses to hepatitis B vaccine have been associated with some host conditions including obesity. Susceptible non-responders to a primary three-dose vaccine series should be revaccinated. Those who maintain a non-responder condition after revaccination with three vaccine doses are unlikely to develop protection using more doses. This is a description of an obese woman who received six doses of hepatitis B vaccine and persisted as a non-responder. She was submitted to a vertical banded gastroplasty Roux-en-Y gastric bypass Capellas's technique. After weight reduction, she received three additional doses of vaccine and seroconverted. Further studies should help clarify the need to evaluate antibody levels and eventually revaccinate the increasing population of individuals who undergo weight reduction.
Databáze: MEDLINE