| Autor: |
Hung TT; Oncology Research Centre, Level 2, Clinical Sciences Building, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia., Wang H, Kingsley EA, Risbridger GP, Russell PJ |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 2008 Jun 28; Vol. 265 (1), pp. 27-38. Date of Electronic Publication: 2008 May 13. |
| DOI: |
10.1016/j.canlet.2008.02.034 |
| Abstrakt: |
A human bladder cancer model of nine cell sublines derived from the BL17/2 cell line was used to evaluate genes related to disease progression. Molecular profiling of sublines that were non-tumorigenic and invasive in nude mice was performed and identified 1367 differentially-expressed genes. Quantitative real-time PCR analysis of six transforming growth factor-beta (TGF-beta) pathway genes using the entire panel of nine cell lines was performed. Bone morphogenetic protein-2 expression was significantly associated with in vivo tumorigenicity of the cell lines (p=0.0228, Mann-Whitney); inhibin-betaB was related to their invasiveness (p=0.0468, Mann-Whitney). Analysis of conditioned medium showed TGF-beta1 production to be significantly associated with the phenotype of the cell line. The study shows the possible involvement of the TGF-beta pathway in bladder cancer progression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect