| Autor: |
Chu DT; Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500., Nordeen CW, Hardy DJ, Swanson RN, Giardina WJ, Pernet AG, Plattner JJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1991 Jan; Vol. 34 (1), pp. 168-74. |
| DOI: |
10.1021/jm00105a025 |
| Abstrakt: |
Temafloxacin hydrochloride [(+/-)-7-(3-methylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro- 4-oxoquinoline-3-carboxylic acid hydrochloride] is a potent member of the 4-pyridone-3-carboxylic acid class of antibacterial agents and is currently under clinical development as a broad-spectrum antimicrobial agent. It is a racemate having a chiral center at the C3 of the 7-piperazin-1-yl group. The two enantiomers were synthesized and tested for their antibacterial activities. Although no difference in in vitro antibacterial activities was observed, a minor difference in in vivo antibacterial activities was observed. However, they both exhibited similar pharmacological profiles. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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