| Autor: |
Paliy O; Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435, USA. oleg.paliy@wright.edu, Gargac SM, Cheng Y, Uversky VN, Dunker AK |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of proteome research [J Proteome Res] 2008 Jun; Vol. 7 (6), pp. 2234-45. Date of Electronic Publication: 2008 May 09. |
| DOI: |
10.1021/pr800055r |
| Abstrakt: |
We considered, on a global scale, the relationship between the predicted fraction of protein disorder and the RNA and protein expression in Escherichia coli. Fraction of protein disorder correlated positively with both measured RNA expression levels of E. coli genes in three different growth media and with predicted abundance levels of E. coli proteins. Though weak, the correlation was highly significant. Correlation of protein disorder with RNA expression did not depend on the growth rate of E. coli cultures and was not caused by a small subset of genes showing exceptionally high concordance in their disorder and expression levels. Global analysis was complemented by detailed consideration of several groups of proteins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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