What's the point of the type III secretion system needle?

Autor: Blocker AJ; Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom., Deane JE, Veenendaal AK, Roversi P, Hodgkinson JL, Johnson S, Lea SM
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 May 06; Vol. 105 (18), pp. 6507-13. Date of Electronic Publication: 2008 May 05.
DOI: 10.1073/pnas.0708344105
Abstrakt: Recent work by several groups has significantly expanded our knowledge of the structure, regulation of assembly, and function of components of the extracellular portion of the type III secretion system (T3SS) of Gram-negative bacteria. This perspective presents a structure-informed analysis of functional data and discusses three nonmutually exclusive models of how a key aspect of T3SS biology, the sensing of host cells, may be performed.
Databáze: MEDLINE