| Autor: |
Sepulveda-Arias JC; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Kempf MC, Wiehr S, Wedekind D, Hedrich HJ, Gross U, Herrmann T |
| Jazyk: |
angličtina |
| Zdroj: |
Parasite immunology [Parasite Immunol] 2008 Jun-Jul; Vol. 30 (6-7), pp. 323-33. Date of Electronic Publication: 2008 Apr 21. |
| DOI: |
10.1111/j.1365-3024.2008.01029.x |
| Abstrakt: |
In immunocompetent rats and humans infection with Toxoplasma gondii remains mostly without overt clinical symptoms, but can be fatal, if the T-cell response is impaired. For a better understanding of the lack of control of T. gondii infection under immunosuppressed conditions, congenitally athymic rats were used as the experimental model. Whereas athymic F344-Whn(rnu) (F344 nude) rats die from a generalized infection during the first 3 weeks after peritoneal inoculation with 10(6) tachyzoites of T. gondii strain NTE, LEW-Whn(rnu) (LEW nude) rats and euthymic LEW rats infected with a 10-fold higher number of parasites developed chronic infection. To identify underlying mechanisms of LEW rats resistance to T. gondii infection and to investigate a possible contribution of residual T-cells to LEW-Whn(rnu) rat resistance, we characterized the immune response of LEW rats by determination of cellularity and composition of lymphocyte population, antigen-specific IgG2b response as well as assays of antigen-specific proliferation and production of IL-2, IFN-gamma and TNF-alpha. As only euthymic LEW rats developed production of antigen-specific IgG and cellular in vitro responses, these results strongly suggest that the genetic background of LEW rats permits a control of the infection independent of an adaptive immune response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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