| Autor: |
Montiel-Equihua CA; Centre for Molecular Oncology, Institute of Cancer and CR-UK Clinical Centre, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK., Martín-Duque P, de la Vieja A, Quintanilla M, Burnet J, Vassaux G, Lemoine NR |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer gene therapy [Cancer Gene Ther] 2008 Jul; Vol. 15 (7), pp. 465-73. Date of Electronic Publication: 2008 Apr 18. |
| DOI: |
10.1038/cgt.2008.6 |
| Abstrakt: |
Expression of the sodium iodide symporter (hNIS) has been detected in breast cancer tissue, but frequently, not at the levels necessary to mediate (131)I accumulation. Transducing the hNIS gene into breast cancer cells with adenovirus could be a tractable strategy to render breast cancer susceptible to radioiodide therapy. We constructed the replication-incompetent virus, AdSERE, in which an estrogen-responsive promoter directs the expression of hNIS. In vitro, we demonstrate that AdSERE mediates hNIS expression and iodide uptake in ER+ breast cancer cells. In vivo, we show that AdSERE-infected ER+ tumors can be imaged due to tracer accumulation; in addition, AdSERE in combination with therapeutic doses of (131)I suppresses tumor growth. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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