| Autor: |
Wolfe JN; National Reference Centre for Mycobacteriology, National Microbiology Laboratory, Public Health Agency of Canada., Blackwood-Antonation KS, Sharma MK, Cook VJ |
| Jazyk: |
angličtina |
| Zdroj: |
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale [Can J Infect Dis Med Microbiol] 2006 May; Vol. 17 (3), pp. 183-5. |
| DOI: |
10.1155/2006/263932 |
| Abstrakt: |
A case of presumed bacillus Calmette-Guérin (BCG) cystitis in an elderly female patient following direct intravesical BCG instillation treatment for papillary transitional cell carcinoma is reported. The organism cultured from urine samples was eventually identified as a rifampin-resistant Mycobacterium bovis BCG isolate. Because the patient had received rifampin monotherapy during the course of treatment for presumed BCG disease, the clinical picture favoured acquired rifampin resistance. Sequencing of the target gene for rifampin (rpoB) confirmed a known mutation responsible for conferring high levels of resistance to both rifampin and rifabutin (Ser531Tyr). To the authors' knowledge, this is the first reported case of M bovis BCG disease in a non-HIV patient where the organism had acquired drug resistance to rifampin, and the second reported case of M bovis BCG that had acquired drug resistance. The present case demonstrates the necessity to re-evaluate appropriate guidelines for the effective treatment of BCG disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text