Severe hemolysis with normal blood count in a glucose-6-phosphate dehydrogenase deficient neonate.

Autor: Kaplan M; Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel. kaplan@cc.huji.ac.il, Hammerman C, Vreman HJ, Wong RJ, Stevenson DK
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2008 Apr; Vol. 28 (4), pp. 306-9.
DOI: 10.1038/sj.jp.7211919
Abstrakt: A premature glucose-6-phosphate dehydrogenase (G-6-PD) deficient neonate was readmitted for exponential rise in the plasma bilirubin concentration to 33.0 mg dl(-1). Blood carboxyhemoglobin (2.8% of total hemoglobin, >threefold normal value) confirmed the presence of hemolysis; however, hematological indices were unchanged from the birth hospitalization. Serum unbound bilirubin, although present, was probably at a concentration insufficient to cause bilirubin encephalopathy. In G-6-PD deficient neonates, severe hemolysis may occur in the absence of hematological changes typical of a hemolytic process.
Databáze: MEDLINE