| Autor: |
Kedar GC; Trius Therapeutics, Inc., 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121, USA. kgc@triusrx.com, Brown-Driver V, Reyes DR, Hilgers MT, Stidham MA, Shaw KJ, Finn J, Haselbeck RJ |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2008 Jun; Vol. 52 (6), pp. 2009-13. Date of Electronic Publication: 2008 Mar 31. |
| DOI: |
10.1128/AAC.01594-07 |
| Abstrakt: |
Targeted antisense and gene replacement mutagenesis experiments demonstrate that only the murA1 gene and not the murA2 gene is required for the normal cellular growth of Bacillus anthracis. Antisense-based modulation of murA1 gene expression hypersensitizes cells to the MurA-specific antibiotic fosfomycin despite the normally high resistance of B. anthracis to this drug. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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