| Autor: |
Jain KS; Sinhgad College of Pharmacy, Pune 411041, India. kishor.s.jain@gmail.com, Bariwal JB, Kathiravan MK, Phoujdar MS, Sahne RS, Chauhan BS, Shah AK, Yadav MR |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 May 01; Vol. 16 (9), pp. 4759-800. Date of Electronic Publication: 2008 Mar 04. |
| DOI: |
10.1016/j.bmc.2008.02.091 |
| Abstrakt: |
Hypertension is one of the most serious health problems of the modern world with a continuous rise in the number of patients. Selective alpha(1)-adrenoreceptor antagonists though have many advantages and uses in the management of arterial hypertension, their lack of specificity at the level of alpha(1)-adr subtypes leads to multiple side effects. Existence of multiple alpha(1)-adr subtypes holds great promise for the discovery and development of more specific and selective drug molecules, targeting only one alpha(1)-adr subtype at a time and thus relative freedom from side effects. Herein, the research done on the discovery and evaluation of a variety of chemically diverse structures as selective antagonists of alpha(1)-adr and alpha(1)-adr subtypes in recent years has been reviewed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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