| Autor: |
Li JJ; Discovery Chemistry, Bristol-Myers Squibb Research and Development, PO Box 5400, Princeton, NJ 08543-5400, USA. James.Li@bms.com, Wang H, Li J, Qu F, Swartz SG, Hernández AS, Biller SA, Robl JA, Tino JA, Slusarchyk D, Seethala R, Sleph P, Yan M, Grover G, Flynn N, Murphy BJ, Gordon D |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Apr 15; Vol. 18 (8), pp. 2536-9. Date of Electronic Publication: 2008 Mar 22. |
| DOI: |
10.1016/j.bmcl.2008.03.059 |
| Abstrakt: |
A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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