| Autor: |
Seixas E; Instituto Gulbenkian de Ciência, Oeiras, Portugal. eseixas@igc.gulbenkian.pt, Oliveira P, Moura Nunes JF, Coutinho A |
| Jazyk: |
angličtina |
| Zdroj: |
Parasitology [Parasitology] 2008 May; Vol. 135 (6), pp. 683-90. Date of Electronic Publication: 2008 Apr 01. |
| DOI: |
10.1017/S0031182008004344 |
| Abstrakt: |
While BALB/c mice survive infection with blood stages of Plasmodium chabaudi chabaudi (AS), 70% of DBA/2 mice die by day 9-11 of infection, both strains controlling parasitaemia. We describe here that infection of DBA/2 mice results in extensive, multifocal hepatocyte death. Antibody neutralization of TNF-alpha prevents both liver damage and death. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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