| Autor: |
Bush CF; Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA., Hall RA |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2008 Aug; Vol. 65 (15), pp. 2289-95. |
| DOI: |
10.1007/s00018-008-8028-z |
| Abstrakt: |
Olfactory receptors typically exhibit poor plasma membrane localization and functionality when heterologously expressed in most cell types. It has therefore proven difficult to effectively study olfactory receptor pharmacology and signaling mechanisms using traditional cell culture systems. Over the past few years, a variety of distinct proteins have been reported to interact with olfactory receptors and facilitate olfactory receptor trafficking to the plasma membrane in heterologous cells. Advances in this area have shed significant light on the fundamental factors governing the cell-specific control of olfactory receptor trafficking. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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