| Autor: |
Berkompas DC; Indiana University Medical Center, Indianapolis. |
| Jazyk: |
angličtina |
| Zdroj: |
Indiana medicine : the journal of the Indiana State Medical Association [Indiana Med] 1991 Nov; Vol. 84 (11), pp. 788-91. |
| Abstrakt: |
Oral anticoagulants are widely used in clinical practice. Hemorrhagic complications are the most frequent adverse reactions, but a rarer complication, coumadin skin necrosis, also can be seen. The recently described association with low levels of protein C and/or free protein S is of importance in the pathophysiology of coumadin skin necrosis. This article describes the case of a patient with a functional protein S deficiency who developed coumadin skin necrosis. The condition is described, and a discussion of theories regarding its pathophysiology is presented. Current treatment recommendations are listed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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