| Autor: |
Novotny VM; Department of Blood Transfusion and Transplantation Immunology (469), Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands. v.novotny@hemat.umcn.nl |
| Jazyk: |
angličtina |
| Zdroj: |
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2007 Dec; Vol. 14 (6), pp. 538-41. Date of Electronic Publication: 2008 Mar 24. |
| DOI: |
10.1016/j.tracli.2008.01.001 |
| Abstrakt: |
Many side-effects of red blood cell transfusion have been described. They include iron-overload, as well as allo- and autoantibody formation against red cells. During storage, erythrocytes undergo complex structural and biochemical changes. It has been suggested that accelerated and/or aberrant forms of the physiological erythrocyte aging process underlie the red cell storage lesion. This storage lesion may contribute to side-effects of transfusion as endothelial damage by release of internal erythrocyte constituents, (pro)inflammatory consequences, hampered microcirculation and oxygen delivery. Understanding the process that determines the fate of red blood cells after transfusion may contribute to the prevention of side-effects after red blood cell transfusion. This should be the focus of research on red blood cell transfusion in clinical transfusion medicine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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