| Autor: |
Boven E; Department of Oncology, Free University Hospital, Amsterdam, The Netherlands., Haisma HJ, Bril H, Martens HJ, van Lingen A, den Hollander W, Kessel MA, DeJager RL, Roos JC |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 1991; Vol. 27 (11), pp. 1430-6. |
| DOI: |
10.1016/0277-5379(91)90025-9 |
| Abstrakt: |
Human IgM monoclonal antibody 16.88 recognised an intracellular antigen strongly expressed in colorectal cancer tissue in 51% of our patients. Tumour localisation was carried out with 185 MBq 131I-16.88 (8 mg) in 20 of these patients with advanced disease. In 16 patients (80%) immunoscintigraphy was positive in at least one organ site with disease. Of all sites, 55% could be visualized. In general, lesions less than 3 cm could not be detected. Sequential immunoscintigrams of liver metastases showed variable patterns. Initial "cold" lesions corresponded to liver metastases with poor blood supply as indicated by 99mTc-sulphur-colloid and 99mTc-HMPAO scintigraphy, respectively. The mean (S.D.) biological half-life (whole body clearance of radioactivity) was 37.6 (5.0) h. A second infusion of 131I-16.88 with the addition of high doses of unlabelled 16.88 could be done safely, but did not result in better visualisation of tumour lesions or affect radioactivity clearance from the body. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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