[Total homocysteine levels in children with diabetes type 1. Conditional factors].

Autor:	Martínez Laborda S; Unidad de Enfermedades Metabólicas, Hospital Infantil Miguel Servet, Zaragoza, Spain. susanamartinezl@hotmail.com, Salazar García-Blanco MI, Rodríguez Rigual M, Baldellou Vázquez A
Jazyk:	Spanish; Castilian
Zdroj:	Anales de pediatria (Barcelona, Spain : 2003) [An Pediatr (Barc)] 2008 Mar; Vol. 68 (3), pp. 264-8.
DOI:	10.1157/13116707
Abstrakt:	Objectives: To measure the plasma levels of total homocysteine (tHcy) in children with type I diabetes mellitus and their relationship with the control of the disease. Material and Methods: We studied a total of 46 patients with ages between 4 and 19 years. The analyzed variables were: sex, age, puberty stage by Tanner, BMI, years of evolution of the illness, self-monitoring, associated diseases, tHcy, folic acid, vitamin B12, glycosylated haemoglobin (HbA1c), lipid profile and renal function. Results: The mean tHcy was of 5.48 +/- 1,64 microm/l, similar to that in our control population. There was a positive correlation with tHcy when analyzing the puberty stage by the Tanner scale. The years of evolution of diabetes varied between 0.4 and 15, with a mean of 5.77 +/- 3.69, with no correlation with tHcy. The glycosylated haemoglobin mean was 7.35 %, with no correlation with tHcy. The levels of folic acid and vitamin B12 were similar to the control population. The lipid profile of our patients was normal, with no association with tHcy levels. There was no correlation between GFR and tHcy. Conclusions: A clinically correct control of children with diabetes mellitus type 1, appears to ensure a normal total homocysteinemia, with no significant differences with the healthy individuals of the same age and social environment.
Databáze:	MEDLINE
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