A case of refractory secondary paroxysmal kinesigenic dyskinesia with high sensitivity to phenytoin monotherapy.

Autor: Bonakis A; Department of Neurology, Athens University Medical School, Eginition Hospital, 74 Vassilissis Sofias Avenue, 11528 Athens, Greece., Papageorgiou SG, Potagas C, Karahalios G, Kalfakis N
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2009 Jan; Vol. 15 (1), pp. 68-70. Date of Electronic Publication: 2008 Mar 18.
DOI: 10.1016/j.parkreldis.2008.01.015
Abstrakt: We report on a 42-year-old man with paroxysmal kinesigenic dyskinesia who was referred as a refractory case to any drug used in the past as monotherapy or in combination. Our decision to discontinue his current combined medication and to administer only high-dose phenytoin led to significant improvement. It is of interest to note that the previous use of phenytoin in combination with other antiepileptic and neuroleptic drugs had no effect. In addition, the co-administration of gabapentin led to a dramatic recurrence of the episodes.
Databáze: MEDLINE