Low DNA HTLV-2 proviral load among women in São Paulo City.

Autor: Montanheiro P; Laboratory of Dermatology and Immunology, São Paulo University Medical School, Sao Paulo, Brazil., Olah I, Fukumori LM, Smid J, Oliveira AC, Kanzaki LI, Fonseca LA, Duarte AJ, Casseb J
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2008 Jul; Vol. 135 (1), pp. 22-5. Date of Electronic Publication: 2008 Mar 17.
DOI: 10.1016/j.virusres.2008.01.015
Abstrakt: Background: HTLV-2 infections are almost always asymptomatic, and diseases associated with the infection are rarely reported. Little information is available on the relationship between HTLV-2 proviral load and gender or expression of disease, especially among patients with HIV-1 co-infection.
Methods: We studied 77 HTLV-2-infected subjects followed in our clinic for the last 9 years; 53 (69%) of them were co-infected with HIV-1. HTLV-2 DNA proviral load (PVL) was measured by real time PCR, a test with a sensitivity of 10 in 10(4) PBMCs.
Results: Six of 53HTLV-2/HIV-1 cases had a myelopathy (all of them had undetectable PVL of HTLV-2). Only 3 of 35 women (2 out of 3 co-infected with HIV) had a detectable PVL, whereas 10 of 42 men had a detectable PVL. Regardless of their HIV status women had significantly lower PVL than men (10 vs. 43 copies/10(4) PBMCs, p<0.05).
Conclusions: We noticed the occurrence of myelopathy in HTLV-2/HIV-1 co-infected patients, with undetectable HTLV-2 viral load. There was a sex difference in viral load for HTLV-2, what may be the result in mode of transmission or acquisition of the virus.
Databáze: MEDLINE
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