Natural killer cells, glutathione, cytokines, and innate immunity against Mycobacterium tuberculosis.

Autor: Millman AC; Division of Infectious Diseases, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA., Salman M, Dayaram YK, Connell ND, Venketaraman V
Jazyk: angličtina
Zdroj: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2008 Mar; Vol. 28 (3), pp. 153-65.
DOI: 10.1089/jir.2007.0095
Abstrakt: It is becoming increasingly apparent that natural killer (NK) cells play a crucial role in innate defense mechanisms against Mycobacterium tuberculosis infection. Furthermore, NK cell functions are dependent on adequate levels of glutathione. In this study, we examined whether the NK cell-mediated growth control of intracellular M. tuberculosis is dependent on adequate levels of glutathione. We investigated the effects of glutathione both alone and in combination with interleukin-2 (IL-2) or IL-12 or both in modulating NK cell functions, such as cytolytic activity, activating receptor expression, induction of apoptosis, and cytokine synthesis. Our results strongly indicate that glutathione in combination with IL-2+IL-12 augments NK cell functions, leading to control M. tuberculosis infection.
Databáze: MEDLINE