Autor: |
Millman AC; Division of Infectious Diseases, UMDNJ-New Jersey Medical School, Newark, NJ 07103, USA., Salman M, Dayaram YK, Connell ND, Venketaraman V |
Jazyk: |
angličtina |
Zdroj: |
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research [J Interferon Cytokine Res] 2008 Mar; Vol. 28 (3), pp. 153-65. |
DOI: |
10.1089/jir.2007.0095 |
Abstrakt: |
It is becoming increasingly apparent that natural killer (NK) cells play a crucial role in innate defense mechanisms against Mycobacterium tuberculosis infection. Furthermore, NK cell functions are dependent on adequate levels of glutathione. In this study, we examined whether the NK cell-mediated growth control of intracellular M. tuberculosis is dependent on adequate levels of glutathione. We investigated the effects of glutathione both alone and in combination with interleukin-2 (IL-2) or IL-12 or both in modulating NK cell functions, such as cytolytic activity, activating receptor expression, induction of apoptosis, and cytokine synthesis. Our results strongly indicate that glutathione in combination with IL-2+IL-12 augments NK cell functions, leading to control M. tuberculosis infection. |
Databáze: |
MEDLINE |
Externí odkaz: |
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