Is there alteration in aortic stiffness in Leber hereditary optic neuropathy?
| Autor: | Nemes A; Department of Cardiology, Thoraxcentre, Erasmus Medical Center, Rotterdam, The Netherlands. nemes@in2nd.szote.u-szeged.hu, De Coo IF, Spruijt L, Smeets HJ, Chinnery PF, Soliman OI, Geleijnse ML, Ten Cate FJ |
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| Jazyk: | angličtina |
| Zdroj: | European journal of ophthalmology [Eur J Ophthalmol] 2008 Mar-Apr; Vol. 18 (2), pp. 309-12. |
| DOI: | 10.1177/112067210801800225 |
| Abstrakt: | Purpose: Leber hereditary optic neuropathy (LHON) is recognized as the most common cause of isolated blindness in young men. The current study was designed to test whether LHON as a mitochondrial disease is associated with vascular functional alterations characterized by aortic elastic properties during echocardiography. Methods: A total of 19 patients with typical features of LHON aged 42+/-13 years (10 males) were included. Their results were compared to 19 age- and gender-matched healthy controls. Aortic stiffness index was calculated from the echocardiographically derived aortic diameters and the clinical blood pressure data. Results: In this patient population, the point mutation was present in 3460G>A position in five cases, in 11778G>A position in five cases, and in 14484T>C position in nine patients. Diastolic aortic diameter (26.0+/-2.5 mm vs 28.4+/-4.1 mm, p<0.05) and aortic stiffness index (5.1+/-2.6 vs 12.0+/-7.9, p<0.05) were significantly increased in LHON patients compared to controls. Conclusions: Aortic stiffness can be increased in LHON disease, but further studies are warranted to confirm these findings in a larger LHON patient population with a more reliable method focusing on the pathophysiologic background. |
| Databáze: | MEDLINE |
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