| Abstrakt: |
Antifungal activity of an adamantane derivative, i. e. 4-(adamantyl-1)-1-(1-aminobutyl) benzol was studied in experiments in vivo in a model of generalized infection and local skin injury. In doses of 0.1 LD50, 0.001 LD50, 0.001 LD50 (intraperitoneal administration) it had a therapeutic effect on generalized candidiasis and promoted 60-80-percent survival of the laboratory animals. Its application as 1-percent ointment to Candida albicans infected skin prevented the wound formation in rabbits and showed therapeutic efficacy in the treatment of infected wounds in albino rats. |
