Effects of antiretroviral therapy on semen quality.
| Autor: | van Leeuwen E; Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands. e.vanleeuwen@amc.uva.nl, Wit FW, Repping S, Eeftinck Schattenkerk JK, Reiss P, van der Veen F, Prins JM |
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| Jazyk: | angličtina |
| Zdroj: | AIDS (London, England) [AIDS] 2008 Mar 12; Vol. 22 (5), pp. 637-42. |
| DOI: | 10.1097/QAD.0b013e3282f4de10 |
| Abstrakt: | Objective: To evaluate the effect of combination antiretroviral therapy (cART) on semen quality. Design: A longitudinal cohort study. Setting: The HIV outpatient clinic of the Academic Medical Centre in Amsterdam, the Netherlands. Subjects: A cohort of 34 male patients with different estimated duration of HIV-1 infection, who were about to start various combinations of cART. Intervention(s): Blood and semen analyses before the start of cART and 4, 12, 24, 36 and 48 weeks thereafter. Main Outcome Measure(s): We examined the effect of cART on semen parameters by a repeated measurements procedure using a mixed-effects model. Results: The median period of follow up was 48 weeks (interquartile range 33-52 weeks). Five patients used thymidine analogue-containing cART, 23 used tenofovir-based cART, six used other regimens. At all timepoints the percentage of progressively motile spermatozoa was low according to WHO criteria, and it decreased significantly from 28 to 17% during follow-up (P = 0.02). All other semen parameters were in the normal range and remained stable. Conclusion: cART negatively affected the percentage of progressively motile spermatozoa. Whether this reduced motility affects the chances of fathering a child or leads to an increased need for artificial reproductive techniques is at present unknown. |
| Databáze: | MEDLINE |
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