Unusual detritylation of tritylated tetrazole in Sartan molecules.

Autor: Srimurugan S; Department of Process Chemistry, Advinus Therapeutics, Bangalore-560058, India., Suresh P, Babu B, Hiriyanna SG, Pati HN
Jazyk: angličtina
Zdroj: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2008 Mar; Vol. 56 (3), pp. 383-4.
DOI: 10.1248/cpb.56.383
Abstrakt: Tritylated tetrazole of 2a underwent unusual detritylation under basic reaction condition during the synthesis of methyl ether of olmesartan medoxomil 1. The unusual detritylation was found to be a common feature in the case of all tetrazole containing Sartan molecules (3-7).
Databáze: MEDLINE