| Autor: |
Hamamura M; Department of Fixed Prosthetics, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan. mitsukohama@nifty.com, Hirata N, Sawada K, Shuto T, Shimazoe T, Terada Y, Fukumaki Y |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2008 Jul; Vol. 115 (7), pp. 959-71. Date of Electronic Publication: 2008 Feb 26. |
| DOI: |
10.1007/s00702-008-0032-9 |
| Abstrakt: |
The cerebellum has a parasagittal modular structure, in which Zebrin (Aldolase) positive and negative bands expressed in Purkinje cell layers alternate, and is involved in amphetamine psychosis. Administration of SKF38393, a D1 receptor agonist, reversed the behavioral sensitization of methamphetamine. In the vermis, there were the binding sites of SKF38393. In methamphetamine-sensitized rats the expression of the Aldolase mRNA positive bands move laterally in the rat vermis. We provide here the evidence that the D1 agonist injections also reversed the expression pattern of both the Aldolase mRNA in Purkinje cells and Ube (ubiquitin activating enzyme) 1x mRNA in Golgi interneurons of the sensitized rats. Thus the reverse changes in gene expression pattern in the vermis may be involved in the mechanisms of the behavioral plasticity and suggests the new treatment of drug abuse. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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