Prognostic importance of tissue Doppler-derived diastolic function in patients presenting with acute coronary syndrome: a bedside echocardiographic study.

Autor:	Richardson-Lobbedez M; Centre Hospitalier Régional et Universitaire de Lille, Intensive Care Unit, Lille F-59019, France., Maréchaux S, Bauters C, Darchis J, Auffray JL, Bauchart JJ, Aubert JM, LeJemtel TH, Lesenne M, Van Belle E, Goldstein P, Asseman P, Ennezat PV
Jazyk:	angličtina
Zdroj:	European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology [Eur J Echocardiogr] 2008 Sep; Vol. 9 (5), pp. 594-8. Date of Electronic Publication: 2008 Feb 07.
DOI:	10.1093/ejechocard/jen005
Abstrakt:	Aims: We sought to evaluate the prognostic value of bedside tissue Doppler derived diastolic function in patients presenting with acute coronary syndrome (ACS) on top of major clinical predictors of mortality and routine laboratory testings. Methods and Results: Bedside Doppler echocardiography and laboratory tests were prospectively performed in 239 consecutive patients (mean age 62 +/- 14, 69% men) admitted for ACS. Ratio of early transmitral flow (E) to early mitral annulus velocities (e') was calculated. The study endpoint was cardiac death. The median follow-up period was 2 years. E/e' was >15 in 39 patients. Multivariate predictors of E/e' > 15 were older age, diabetes, non-ST-segment elevation ACS, and decreased LV ejection fraction (LVEF). Survival free from cardiac death was lower in patients with E/e' ratio >15 (P = 0.01). History of coronary artery disease, lower creatinine clearance, higher glycemia on admission, decreased LVEF, and E/e' >15 were independent predictors of cardiac death. Conclusion: Bedside Doppler echocardiography provides prognostic information on top of major clinical predictors of mortality and routine laboratory testings in patients presenting with ACS.
Databáze:	MEDLINE
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