| Autor: |
Rozsíval P; Charles University in Prague, Faculty of Medicine, Hradec Králové. pavel.rozsival@seznam.cz, Parízková E, Vokurková D, Buriánková B, Andrýs C |
| Jazyk: |
angličtina |
| Zdroj: |
Acta medica (Hradec Kralove) [Acta Medica (Hradec Kralove)] 2007; Vol. 50 (4), pp. 229-31. |
| Abstrakt: |
Due to immaturity of both specific and non-specific immune mechanisms, neonates are at risk of serious infections. The risk group definition is vague, clinical signs are non-specific and common laboratory markers are not as useful as in later ages, especially due to delayed reactions. In an attempt to find early, sensitive and specific markers, we assessed a defined set of surface leukocyte markers and humoral factors in cord blood. Several differences were noted--children in the risk group had a higher proportion of CD19+/23+, CD16+/64+, CD45RO cells and higher levels of IL-6. We find it promising that already at birth there are notable signs of reaction to infection and that a follow-up of a set of infectious markers could be useful to identify the children in need of antibiotic treatment and for diminishing unnecessary treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
