[A case of advanced gastric cancer successfully treated by combination therapy of S-1 and docetaxel].

80 mg/body, DOC 40--> 32 mg/m2). The response was maintained on CT and endoscopic examination after 21 courses of treatment. A case of an advanced gastric cancer patient successfully treated by combination therapy of S-1 and DOC was reported. -->
Substance Nomenclature: 0 (Biomarkers, Tumor)
0 (Drug Combinations)
0 (Taxoids)
150863-82-4 (S 1 (combination))
1548R74NSZ (Tegafur)
15H5577CQD (Docetaxel)
5VT6420TIG (Oxonic Acid)
Entry Date(s): Date Created: 20080219 Date Completed: 20080404 Latest Revision: 20181201
Update Code: 20221213
PMID: 18281767
Autor: Ikarashi S; Dept. of Internal Medicine, Niigata Cancer Center Hospital., Akiyama N, Motoyama H, Sasaki S, Ito H, Funakoshi K, Kato T, Arai F
Jazyk: japonština
Zdroj: Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2008 Feb; Vol. 35 (2), pp. 287-90.
Abstrakt: A 70-year-old man with gastric cancer of Borrmann type 3, liver metastases and peritoneal dissemination was treated by combination therapy of S-1 and docetaxel (DOC). He received DOC intravenously at 40 mg/m(2) on day 1 and S-1 orally at 100 mg/body on day 1 to 14, repeated every 28 days. After 2 courses of treatment, a CT scan revealed improvement of the gastric wall thickness, the eminent decrease of the peritoneal fluid and the reduction of the liver metastasis. After 3 courses of treatment, the primary lesion was remarkably improved on endoscopic examination, and the tumor marker normalized after 4 courses of treatment. Toxicities included leukocytopenia (WHO grade 3), neutropenia ( grade 3), anorexia (grade 2), and nausea (grade 2). Outpatient chemotherapy was possible by reduction of dose (S-1 100--> 80 mg/body, DOC 40--> 32 mg/m2). The response was maintained on CT and endoscopic examination after 21 courses of treatment. A case of an advanced gastric cancer patient successfully treated by combination therapy of S-1 and DOC was reported.
Databáze: MEDLINE
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