| Autor: |
Cedraz-Mercez PL; Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 23890-000, Brazil., Almeida AC, Thomaz CM, Costa-e-Sousa RH, Olivares EL, Côrtes WS, Medeiros MA, Reis LC |
| Jazyk: |
angličtina |
| Zdroj: |
Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2007 Nov; Vol. 67 (4), pp. 771-6. |
| DOI: |
10.1590/s1519-69842007000400027 |
| Abstrakt: |
The purpose of this study was to explore the role of L-5-hydroxytryptophan (L-HTP) and its relationship with the renin-angiotensin system (RAS) on the drinking behavior in Japanese quails. Normally-hydrated quails that received injections of L-HTP (12.5; 25 and 50 mg.kg-1) by the intracoelomic route (ic) expressed an increase in water intake, which was inhibited by captopril, an angiotensin converting enzyme (ACE) inhibitor. In addition, captopril also induced such a response in birds under previous fluid deprivation. High doses of captopril (35-70 mg.kg-1, sc) in normally-hydrated quails decreased the spontaneous water intake while low doses of captopril (2-5 mg.kg-1, sc) did not prompt water intake after L-HTP administration. Losartan, an AT1 receptor antagonist in mammals, did not change the water intake levels in normally-hydrated or water-deprivated birds. Serotonin (5-HT) injections did not provoke its known dipsogenic response. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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