Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.

Autor: Grillet F; Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France., Baumlová B, Prévost G, Constant JF, Chaumeron S, Bigg DC, Greene AE, Kanazawa A
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Mar 15; Vol. 18 (6), pp. 2143-6. Date of Electronic Publication: 2008 Jan 30.
DOI: 10.1016/j.bmcl.2008.01.082
Abstrakt: A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
Databáze: MEDLINE