| Autor: |
Chinen LK; Covidien, Inc., 675 McDonnell Boulevard, Hazelwood, Missouri 63042, USA., Galen KP, Kuan KT, Dyszlewski ME, Ozaki H, Sawai H, Pandurangi RS, Jacobs FG, Dorshow RB, Rajagopalan R |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 2008 Feb 28; Vol. 51 (4), pp. 957-62. Date of Electronic Publication: 2008 Feb 06. |
| DOI: |
10.1021/jm070842+ |
| Abstrakt: |
Real-time, noninvasive assessment of glomerular filtration rate (GFR) is essential not only for monitoring critically ill patients at the bedside, but also for staging and monitoring patients with chronic kidney disease. In our pursuit to develop exogenous luminescent probes for dynamic optical monitoring of GFR, we have prepared and evaluated Eu(3+) complexes of several diethylenetriamine pentaacetate (DTPA)-monoamide ligands bearing molecular "antennae" to enhance metal fluorescence via intramolecular ligand-metal fluorescence resonance energy transfer process. The results show that Eu-DTPA-monoamide complex 18b, which contains a quinoxanlinyl antenna, exhibits large (ca. 2700-fold) Eu(3+) fluorescence enhancement. Indeed, complex 18b exhibits the highest fluorescent enhancement observed thus far in the DTPA-type metal complexes. The renal clearance property was assessed using the corresponding radioactive (111)In complex 18a, and the data suggest that this complex clears via a complex mechanism that includes glomerular filtration. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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