| Autor: |
Atheaya H; Department of Chemistry, University of Delhi, Delhi 110007, India., Khan SI, Mamgain R, Rawat DS |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Feb 15; Vol. 18 (4), pp. 1446-9. Date of Electronic Publication: 2008 Jan 01. |
| DOI: |
10.1016/j.bmcl.2007.12.069 |
| Abstrakt: |
Symmetrically and asymmetrically substituted 1,2,4,5-tetraoxanes were synthesized by the oxidative system H(2)O(2)/TFE in presence of MeReO(3) as a catalyst. All of the synthesized compounds were characterized spectroscopically, and evaluated for cytotoxicity, and antimalarial activity. Several of these tetraoxanes exhibited in vitro antimalarial activity without showing any cytotoxicity. Thermal stability of these compounds was studied by differential scanning calorimetry. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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