| Autor: |
Kolik LG; Department of Pharmacogenetics, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. lgkolik@email.ru, Zhukov VN, Seredenin SB |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2007 Jun; Vol. 143 (6), pp. 703-5. |
| DOI: |
10.1007/s10517-007-0219-3 |
| Abstrakt: |
Experiments on outbred mice showed that compound GB-115, a retropeptide analogue of the tetrapeptide cholecystokinin, produced a naloxone-dependent potentiating effect on morphine-induced analgesia in the hot-plate test, but did not modulate animal behavior in the tail-flick test in outbred mice. This potentiation of antinociceptive activity of morphine was probably related to the interaction of GB-115 with supraspinal opioidergic mechanisms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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