| Autor: |
Gumanova NG; State Research Institute of Preventive Medicine, Ministry of Health of the Russian Federation, Moscow., Artyushkova EB, Metel'skaya VA, Kochkarov VI, Pokrovskaya TG, Danilenko LM, Korneev MM, Pokrovskii MV, Pashin EN |
| Jazyk: |
English; Russian |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2007 Jun; Vol. 143 (6), pp. 678-81. |
| DOI: |
10.1007/s10517-007-0212-x |
| Abstrakt: |
We studied the effects of antioxidants resveratrol and pQ510 on physiological parameters and the state of endothelial NO-synthase as a marker of the regulatory function of the endothelium in the aorta of rats with modeled arterial hypertension. The antioxidants promoted recovery of stable NO metabolites in rat serum and maintained expression of endothelial NO-synthase at a normal level. These effects were confirmed by correction of blood pressure and endothelium-dependent vascular dilation assessed by endothelial dysfunction coefficient. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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