Protective effect of low-doses of antibodies to S-100 protein on the formation of long-term sensitization in helix lucorum.

Autor: Epstein OI; Materia Medica Company, Moscow, Russia., Stark MB, Timoshenko AKh, Gainutdinova TKh, Gainutdinov KhL
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2007 May; Vol. 143 (5), pp. 559-62.
DOI: 10.1007/s10517-007-0179-7
Abstrakt: Injection of antibodies to Ca-binding protein S-100 in a dilution of 10(-12) before the formation of long-term sensitization in Helix lucorum (10 min before the first electric shock) prevented the increase in defense reactions of pneumostome closure and ommatophore withdrawal. Thus, we demonstrated a protective effect of low-dose antibodies to S-100 on the formation of long-term sensitization as a neurobiological model of anxiety and depression.
Databáze: MEDLINE
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