| Autor: |
Yu F; School of Public Security, Gansu Institute of Political Science and Law, Lanzhou 730070, China. fyu@ufl.edu, Lu S, Yu F, Shi J, McGuire PM, Wang R |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2008 Feb; Vol. 60 (2), pp. 253-9. |
| DOI: |
10.1211/jpp.60.2.0015 |
| Abstrakt: |
We have investigated the cytotoxic and antitumour activity of an octadecenoic acid extract, mainly containing oleic and linoleic acids, from Euphorbia kansui on human gastric (SGC-7901), hepatocellular carcinoma (BEL-7402), and leukaemia (HL-60) tumour cell strains. Significant and dose-dependent antiproliferation effects were observed on tumour cells from the dose of 3.2 microg mL(-1), which were comparable with or better than those of the common antitumour agent 5-fluorouracil. Results from the clone formation assay and flow cytometry indicated that the mixture of octadecenoic acids resulted in a dose-dependent reduction in the number of tumour cells and significantly inhibited cell proliferation, with induced apoptosis and G(0)/G(1) phase cell cycle arrest. Also, the octadecenoic acids could not only cause cell apoptosis/necrosis but also functionally and structurally damage the tumour cell membrane and cell ultra-structures. These observations encourage further clinical evaluation of the inhibitory effects of octadecenoic acids on various forms of cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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