| Autor: |
Berry GP; Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. gearoid.berry@icr.ac.uk, Bamber JC, Mortimer PS, Bush NL, Miller NR, Barbone PE |
| Jazyk: |
angličtina |
| Zdroj: |
Ultrasound in medicine & biology [Ultrasound Med Biol] 2008 Apr; Vol. 34 (4), pp. 617-29. Date of Electronic Publication: 2008 Jan 25. |
| DOI: |
10.1016/j.ultrasmedbio.2007.10.007 |
| Abstrakt: |
Poroelastic theory predicts that compression-induced fluid flow through a medium reveals itself via the spatio-temporal behaviour of the strain field. Such strain behaviour has already been observed in simple poroelastic phantoms using generalised elastographic techniques (Berry et al. 2006a, 2006b). The aim of this current study was to investigate the extent to which these techniques could be applied in vivo to image and interpret the compression-induced time-dependent local strain response in soft tissue. Tissue on both arms of six patients presenting with unilateral lymphoedema was subjected to a sustained compression for up to 500 s, and the induced strain was imaged as a function of time. The strain was found to exhibit time-dependent spatially varying behaviour, which we interpret to be consistent with that of a heterogeneous poroelastic material. This occurred in both arms of all patients, although it was more easily seen in the ipsilateral (affected) arm than in the contralateral (apparently unaffected) arm in five out of the six patients. Further work would appear to be worthwhile to determine if poroelasticity imaging could be used in future both to diagnose lymphoedema and to explore the patho-physiology of the condition. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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