| Autor: |
Bausch CC; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA., Johnson JS |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2008 Feb 15; Vol. 73 (4), pp. 1575-7. Date of Electronic Publication: 2008 Jan 23. |
| DOI: |
10.1021/jo701778k |
| Abstrakt: |
The conjugate addition of dialkylzinc reagents to allyl fumarates with subsequent Ireland-Claisen rearrangement has been accomplished yielding substituted unsymmetrical succinic acid derivatives. This one-pot reaction creates two new carbon-carbon bonds at contiguous stereogenic centers. The reaction proceeds for several alkylzinc reagents and substituted allyl fumarates. The products contain distinguishable functional handles for further manipulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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