Four cardiac hormones eliminate up to two-thirds of human breast cancers in athymic mice.

Autor:	Vesely DL; Department of Internal Medicine, University of South Florida Cardiac Hormone Center, Tampa, FL 33612, USA. david.vesely@med.va.gov, Vesely BA, Eichelbaum EJ, Sun Y, Alli AA, Gower WR Jr
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2007 Nov-Dec; Vol. 21 (6), pp. 973-8.
Abstrakt:	Background: Four cardiac hormones i.e. atrial natriuretic peptide (ANP), vessel dilator, long acting natriuretic peptide (LANP) and kaliuretic peptide have anticancer effects in vitro. Materials and Methods: These four cardiac hormones were infused subcutaneously for 28 days with weekly fresh hormones at 3 nM min(-1) kg(-1) body weight in athymic mice bearing human breast adenocarcinomas. Results: Vessel dilator, LANP, kaliuretic peptide and ANP eliminated 67%, 50%, 67% and 33% of the HTB-132 human breast adenocarcinomas. LANP eliminated 100% and vessel dilator 1/3 of CRL-2327 breast adenocarcinomas. There was no recurrence of the breast cancers in the primary site and no metastasis except in the ANP-treated group in one year post-treatment. The natriuretic peptide receptors-A and -C were decreased 50% and 31%, respectively, in metastatic versus primary ANP-treated breast adenocarcinomas. Conclusion: Four cardiac hormones eliminate up to two-thirds of human breast adenocarcinomas in athymic mice.
Databáze:	MEDLINE
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