| Autor: |
Oliveira EP; Faculdades de Farmácia, Universidade Federal da Bahia, Salvador, BA. epo@ufba.br, Lima Md, Souza ML |
| Jazyk: |
portugalština |
| Zdroj: |
Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2007 Dec; Vol. 51 (9), pp. 1506-15. |
| DOI: |
10.1590/s0004-27302007000900014 |
| Abstrakt: |
The diagnosis of the metabolic syndrome (MS) according to the National Cholesterol Education Program Adult Treatment Panel III does not reflect necessarily the presence of insulin resistance (IR), a potential therapeutical target for type 2 diabetes and cardiovascular disease prevention. Based on previous prevalence data, a cross-sectional study was conducted to determine the HOMA-IR relationship to the MS and some associated abnormalities. HOMA-IR > was higher in individuals with the MS (2.8+/-1.6 vs. 1.8+/-1.4) (p < 0.001). HOMA-IR >or= 2.5 allied good specificity and sensitivity levels for the association of MS and IR. Hyperglycemia, hypertrigliceridemia, and abdominal obesity, the MS components best related to IR, were statistically associated with HOMA-IR > 2.5, but not hypertension neither low HDL-c. The demonstration that some of MS phenotypes or associated abnormalities were more predictive for IR could point out to the possibility of the use of the index as a marker of the presence of IR associated to MS. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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