COR3224--a new antidepressant: pharmacokinetics and metabolism in rat.

Autor: Neau B; Centre de Recherche, Laboratories Sorget, Mérignac, France., Damaj I, Lambrey B, Akbaraly JP, Roux J, Perrissoud D, Jacquot J
Jazyk: angličtina
Zdroj: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 1991; Vol. Spec No 3, pp. 77-9.
Abstrakt: COR3224 is a new 2-amino-2 oxazoline derivative with antidepressant properties. The distribution, excretion and metabolism of radiochemically labelled 14C-COR3224 has been investigated in the rat after intravenous injection. The compound was widely distributed and rapidly excreted. Hydroxylation and sulphate conjugation are involved in the COR3224 elimination.
Databáze: MEDLINE