Centrally located body fat is related to inflammatory markers in healthy postmenopausal women.

Autor: Perry CD; Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA., Alekel DL, Ritland LM, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko OA, Kohut ML, Reddy MB, Van Loan MD, Genschel U
Jazyk: angličtina
Zdroj: Menopause (New York, N.Y.) [Menopause] 2008 Jul-Aug; Vol. 15 (4 Pt 1), pp. 619-27.
DOI: 10.1097/gme.0b013e318159f1a2
Abstrakt: Objective: C-reactive protein and fibrinogen are established atherosclerotic cardiovascular disease risk factors. These acute-phase proteins and the proinflammatory cytokines tumor necrosis factor alpha, interleukin-6, and interleukin-1beta may be elevated in obesity and with menopause. The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women.
Design: We used dual-energy x-ray absorptiometry to assess overall and regional body composition (fat mass in particular) in 242 postmenopausal women in relation to plasma fibrinogen, serum C-reactive protein, and these proinflammatory cytokines.
Results: Multiple regression analyses revealed that 36% of the variability in C-reactive protein (F = 32.4, P Conclusion: Further study is warranted to determine the responsiveness of these acute-phase proteins and cytokines to loss of body fat through exercise and dietary intervention in postmenopausal women.
Databáze: MEDLINE
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