| Autor: |
Hladunewich MA; Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. michelle.hladunewich@sunnybrook.ca, Myers BD, Derby GC, Blouch KL, Druzin ML, Deen WM, Naimark DM, Lafayette RA |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2008 Mar; Vol. 294 (3), pp. F614-20. Date of Electronic Publication: 2008 Jan 16. |
| DOI: |
10.1152/ajprenal.00470.2007 |
| Abstrakt: |
We evaluated the early postpartum recovery of glomerular function over 4 wk in 57 women with preeclampsia. We used physiological techniques to measure glomerular filtration rate (GFR), renal plasma flow, and oncotic pressure (pi(A)) and computed a value for the two-kidney ultrafiltration coefficient (K(f)). Compared with healthy, postpartum controls, GFR was depressed by 40% on postpartum day 1, but by only 19% and 8% in the second and fourth postpartum weeks, respectively. Hypofiltration was attributable solely to depression, at corresponding postpartum times, of K(f) by 55%, 30%, and 18%, respectively. Improvement in glomerular filtration capacity was accompanied by recovery of hypertension to near-normal levels and significant improvement in albuminuria. We conclude that the functional manifestations of the glomerular endothelial injury of preeclampsia largely resolve within the first postpartum month. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
