Behavioral performance modulates spike field coherence in monkey prefrontal cortex.

Autor: Wu W; Frankfurt International Graduate School for Science, Johann Wolfgang Goethe University, Frankfurt, Germany., Wheeler DW, Staedtler ES, Munk MH, Pipa G
Jazyk: angličtina
Zdroj: Neuroreport [Neuroreport] 2008 Jan 22; Vol. 19 (2), pp. 235-8.
DOI: 10.1097/WNR.0b013e3282f49b29
Abstrakt: To investigate neuronal processing during short-term memory, we analyzed behavior-related modulations of coupling between signals on two spatial scales: first, very local multiunit activity and second, local field potentials. Coupling was assessed by spike field coherence using a new approach to overcome limitations in cases of low firing rates. We demonstrate the reliability of our approach with simulated data. Application to recordings in prefrontal cortex of two monkeys revealed that locking of spikes was differentially modulated with two different frequency bands depending on behavioral performance.
Databáze: MEDLINE