| Autor: |
Celebi N; Department of Pharmaceutical Technology, Faculty of Pharmacy, Gazi University, Ankara, Turkey., Iscanoglu M, Degim T |
| Jazyk: |
angličtina |
| Zdroj: |
Die Pharmazie [Pharmazie] 1991 Dec; Vol. 46 (12), pp. 863-5. |
| Abstrakt: |
The effect of beta-cyclodextrin (beta-CD) on the release of naproxen (1) from fatty suppository bases was investigated. The solid complexes of 1 with beta-CD in a molar ratio of 1:1 were prepared by using the kneading, co-precipitation and grinding method. Witepsol H15 and Massa Estarinum B suppositories were prepared, containing the intact 1 and 1-beta-CD complex, respectively. The in vitro release of 1 from fatty bases was examined. The release data were assessed kinetically. The best fit was obtained with Q vs. the square root of time. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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